Search results for "Cognitive architecture"
showing 10 items of 117 documents
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective.
2020
International audience; Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug targets which have been studied intensively in the past few decades. Although several drugs have been approved in this field, they are still limited to a subset of hematological malignancies (in particular T-cell lymphomas), with therapeutic potential not fully realized and the drug-resistance occurred after a certain period of use. To maximize the therapeutic potential of these classes of anticancer drugs, and to extend their application to solid tumors, numerous combination therapies containing an HDACi and an anticancer agent from other mechanisms are currently ongoing in clin…
2018
Despite major progress in Robotics and AI, robots are still basically "zombies" repeatedly achieving actions and tasks without understanding what they are doing. Deep-Learning AI programs classify tremendous amounts of data without grasping the meaning of their inputs or outputs. We still lack a genuine theory of the underlying principles and methods that would enable robots to understand their environment, to be cognizant of what they do, to take appropriate and timely initiatives, to learn from their own experience and to show that they know that they have learned and how. The rationale of this paper is that the understanding of its environment by an agent (the agent itself and its effect…
Some reflections on semantic–pragmatic cycles
2020
Abstract This paper explores novel ways to consider semantic–pragmatic cycles using a dual strategy: an inwards strategy, whereby the distinctive traits of a pragmatic cycle are established, and an outwards strategy, whereby the categories that delimit semantic–pragmatic cycles are described. The result of this exploration is the distinction between “pragmatic cycle”, “replication”, “concomitance” and “paradigmatic increase” as four different yet related processes. In addition, this study integrates Construction Grammar into the description of each process and shows that the study of semantic–pragmatic cycles can benefit from a constructional approach, adopting Traugott and Trousdale’s (201…
Why Digital Games Can Be Advantageous in Vocabulary Learning
2021
Vocabulary learning is an integral part of language learning; however, it is difficult. Although there are many techniques proposed for vocabulary learning and teaching, researchers still strive to find effective methods. Recently, digital games have shown potentials in enhancing vocabulary acquisition. A majority of studies in digital game-based vocabulary learning (DGBVL) literature investigate the effectiveness of DGBVL tasks. In other words, there are enough answers to what questions in DGBVL literature whereas why questions are rarely answered. Finding such answers help us learn more about the structure of the DGBVL tasks and their effects on vocabulary learning. Hence, to achieve this…
The Structured Assessment Dialogue
2017
The two key purposes of assessment, formative and summative, are often in a contradictory position if they are used concurrently. The summative assessment of learning will often prevent the formative assessment for learning to be realised (Butler, J Educ Psychol 79(4):474, 1987), meaning that the learning potential of the assessment will often be minimal. It is therefore a central challenge to find ways to combine the dual use of assessment. The structured assessment dialogue (SAD) is a candidate for such a combination.
The internally layered foot in Dutch
2017
AbstractRecent metrical studies have proposed that, under certain circumstances, a weak syllable may be adjoined to a binary foot, giving rise to a minimally recursive foot. Adding to a growing body of research from metrical stress and foot-conditioned phenomena in various languages, the goals of this paper are twofold. First, we aim at providing empirical evidence for internally layered feet based on the distribution of three foot-conditioned processes of Dutch: vowel reduction, glottal stop /ʔ/ insertion and /h/ licensing/deletion. Second, we explore a less studied theoretical and descriptive advantage of internally layered feet: their potential to predict phonological strength distinctio…
P4571PFA-100, a test of platelet adhesion/aggregation, predicts cardiovascular events after an acute coronary syndrome and can help in the decision-m…
2019
Abstract Background The dual antiplatelet therapy (DAPT) duration is a matter of great interest among cardiologists. Because of the conflicting evidences and the necessity to balance the reduction in major cardiac events (MACE) occurrence and the risk of major bleedings after an acute coronary syndrome (ACS), there is a general consensus on prolonging DAPT on an individual basis. There is less consensus on which parameters are to be evaluated. Nowadays tests of platelet reactivity are not included in the decision-making. Few data are available on the prognostic value of aspirin response tests that are sensitive to other mediators of platelet adhesion and aggregation in vivo under flow condi…
Fatigue does not conjointly alter postural and cognitive performance when standing in a shooting position under dual-task conditions
2017
ABSTRACTThis study investigated the effects of fatigue on balance control and cognitive performance in a standing shooting position. Nineteen soldiers were asked to stand while holding a rifle (single task – ST). They also had to perform this postural task while simultaneously completing a cognitive task (dual task – DT). Both the ST and DT were performed in pre- and post-fatigue conditions. In pre-fatigue, participants achieved better balance control in the DT than in the ST, thus suggesting that the increased cognitive activity associated with the DT improves balance control by shifting the attentional focus away from a highly automatised activity. In post-fatigue, balance control was deg…
36 Altered Prefrontal Cortex Responses in Older Adults with Subjective Memory Complaints and Dementia During Dual-Task Gait: An Fnirs Study
2019
Abstract In this study, we investigated the effects of walking during single-task and dual-task gait (STG and DTG) conditions, on left prefrontal cortex (LPFC) activation in older adults with subjective memory complaints (SMC) and Dementia. A total of 72 older adults (aged 65-94 yrs; 33 Healthy; 28 SMC; 11 Dementia) were recruited from the community and assisted living facilities. A portable 7m zeno walkway gait analysis mat was used to measure stride, velocity, length and duration during 4 passes of STG and DTG each. A portable single-channel functional near-infrared spectroscopy (fNIRS) device (Portalite, Artinis Medical Systems) was placed over the LPFC to measure changes in oxyhaemoglob…
A cognitive architecture for human-robot teaming interaction
2019
Human-robot interaction finalized to cooperation and teamwork is a demanding research task, both under the development and the implementation point of view. In this context, cognitive architectures are a useful means for representing the cognitive perception-action cycle leading the decision-making process. In this paper, we present ongoing work on a cognitive architecture whose modules consider the possibility to represent the decision-making process starting from the observation of the environment and also of the inner world, populated by trust attitudes, emotions, capabilities and so on, and the world of the other in the environment.